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After 3 months of 2mg four times a day, with no change in glucose levels my doctor and I sat down for a talk. When asked if there was a ceiling for the dosages he said we have plenty of room to adjust (there actually is no recorded max dose I could find in the literature). The typical patient uses about 4 mg four times a day. I have found that I have had to increase as much as 16mg four times a day to see adequate glucose changes. It's ease of use and small size makes it easier to take than some, but I have yet to find it's stable dosage for ME.